Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
O-ASCs supply cancer cells with the pool of L-arginine for NO synthesis. The conversion of L-arginine into citrulline is through nitric oxide synthase (NOS). Moreover, secreted citrulline by cancer cells is consumed by O-ASCs and enhances adipogenicity of O-ASCs. The generated NO may induce s-nitrosylation of metabolic enzymes and may alter ovarian cancer cell metabolism.
