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. 2015 Nov 1;11(12):1363–1375. doi: 10.7150/ijbs.13240

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Knockdown of Sox4 inhibits cell migration and colony formation. (A) Expression of Sox4 protein in a panel of bladder cancer cell lines. Increased Sox4 level is revealed by immunoblot in the 6p22-amplicon-containing 5637 and TCC-SUP cells. (B) Knockdown of Sox4 in RT-112 cells as confirmed by immunoblot (β-actin was used as a loading control). (C) Knockdown of Sox4 has no effect on RT-112 cell proliferation examined by MTT assay. (D) Knockdown of Sox4 inhibits cell migration in the transwell cell migration assay. (E) Knockdown of Sox4 inhibits the clonogenicity potential. (F) Loss-of-function Sox4 reduces the colony formation in soft agar.