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. 2015 Nov 1;11(12):1376–1389. doi: 10.7150/ijbs.13109

Figure 9.

Figure 9

An association between AR and Ki-67 in endometrial epithelial cells in women with hyperplasia regardless of the presence of PCOS. Differential expression and localization of endometrial epithelial Ki-67 in women with and without PCOS (A). Values are expressed as mean ± SEM. * p < 0.05 compared to non-PCOS; ### p < 0.001 compared to the proliferative phase. Representative immunofluorescent images of nuclear Ki-67 in endometrial epithelial and stromal cells in the proliferative phase of healthy women are shown. Localization of endometrial AR and Ki-67 in women with hyperplasia (B1 and B2) and in women with PCOS and with hyperplasia (C1 and C2) and in women with PCOS and without hyperplasia (D1 and D2). Endometrial sections were immunolabeled for AR and Ki-67 and visualized with the appropriate wavelength for AR (red) and Ki-67 (green) and then counterstained with DAPI to visualize cell nuclei (blue). Confocal microscopy revealed that AR negatively colocalized with Ki-67 in epithelial cells in women with PCOS but without hyperplasia. Arrowheads indicate colocalization of AR and Ki-67. GE, glandular epithelial cells; Str, stromal cells.