Table 4.
MT2A gene −5 A/G rs28366003 polymorphism in relation to age, gender and smoking status in an inverted papilloma (cases) and non-papilloma cases (controls)
| Variable | Genotype n (%) | p a | |||
|---|---|---|---|---|---|
| A/A | A/G | G/G | |||
| IP—cases | |||||
| Age | <50 years (n = 49) | 40 (30.8) | 8 (6.1) | 1 (0.8) | 0.42 |
| ≥50 years (n = 81) | 58 (44.6) | 23 (17.7) | 0 (0.0) | ||
| <50 years (years ± SD) | 47.9 ± 15.8 | 46.8 ± 12.34 | 47 | - | |
| ≥50 years (years ± SD) | 62.1 ± 13.9 | 52.0 ± 16.5 | - | ||
| Gender | Male (n = 89) | 59 (45.4) | 29 (22.3) | 1 (0.8) | 0.006 |
| Female (n = 41) | 39 (30.0) | 2 (1.5) | 0 (0.0) | ||
| Smoking status | Smokers (n = 71) | 51 (39.2) | 19 (14.6) | 1 (0.9) | 0.77 |
| Non-smokers (n = 59) | 47 (36.1) | 12 (9.2) | 0 (0.0) | ||
| non-IP—controls | |||||
| Age | <50 years (n = 190) | 185 (44.2) | 5 (1.2) | 0 (0.0) | 0.17 |
| ≥50 years (n = 228) | 216 (51.7) | 12 (2.9) | 0 (0.0) | ||
| <50 years (years ± SD) | 53.1 ± 14.6 | 46.2 ± 11.4 | – | – | |
| ≥50 years (years ± SD) | 67.3 ± 12.5 | 51.1 ± 12.1 | – | ||
| Gender | Male (n = 314) | 305 (73.0) | 9 (2.1) | 0 (0.0) | 0.03 |
| Female (n = 104) | 96 (23.0) | 8 (1.9) | 0 (0.0) | ||
| Smoking status | Smokers (n = 141) | 128 (30.6) | 13 (3.1) | 0 (0.0) | 0.0001 |
| Non-smokers (n = 277) | 273 (65.3) | 4 (1.0) | 0 (0.0) | ||
aThe chi-square (χ2) test