Table 6.
Associations between clinicopathological characteristics and papilloma inverted risk
| Variable | SNP rs28366003 | OR (95 % CI)a | p | OR (95 % CI)b | p | |
|---|---|---|---|---|---|---|
| AA n (%) | AG or GG n (%) | |||||
| Stage (Krouse system) pT1 vs. pT2–T4 | 39 (30.0)/59 (45.4) | 1 (0.8)/31 (23.8) | 20.49 (2.34–179.64) | <0.0001 | 19.32 (2.30–173.53) | <0.0001 |
| Histological type exo vs. endophytic | 11 (8.5)/87 (66.9) | 2 (1.5)/30 (23.1) | 1.89 (0.39–9.14) | 0.41 | 1.87 (0.40–9.14) | 0.42 |
| Anatomical areac NS/M/EA vs. EP/F/S | 81 (62.3)/17 (13.1) | 22 (16.9)/10 (7.7) | 2.16 (0.86–5.47) | 0.09 | 2.15 (0.86–5.39) | 0.08 |
| Anatomical sites 1 region vs. more | 55 (42.3)/43 (33.1) | 7 (5.4)/25 (19.2) | 4.57 (1.72–12.11) | 0.0008 | 4.58 (1.70–12.11) | 0.0008 |
| Dysplasia no vs. yes (mild/severe) | 76 (58.5)/22 (16.9) | 12 (9.2)/20 (15.4) | 2.13 (0.92–4.90) | 0.07 | 2.14 (0.97–4.91) | 0.07 |
| Bone destruction no vs. yes | 85 (65.4)/9 (6.9) | 25 (19.2)/11 (8.5) | 4.15 (1.49–11.60) | 0.003 | 4.13 (1.50–11.60) | 0.003 |
| Recurrences no vs. yes | 90 (69.2)/8 (6.2) | 22 (16.9)/10 (7.7) | 5.11 (1.71–15.21) | 0.001 | 5.11 (1.68–15.20) | 0.001 |
aCrude, AA vs. AG or GG MT2A SNP rs28366003 (the homozygote of the common allele were estimated as the reference group)
bAdjusted for age, gender, family history and smoking status
cIn NS/M/EA cases only nasal cavity, maxillary sinuses and/or ethmoid anterior sinuses were occupied; In EP/F/S cases besides nasal cavity, maxillary sinuses and/or ethmoid anterior sinuses the other anatomical sites such as ethmoid posterior sinuses, frontal sinuses and/or sphenoid sinuses were occupied simultaneously (NC nasal cavity, M maxillary sinuses, EA ethmoid anterior sinuses, EP ethmoid posterior sinuses, F frontal sinuses, S sphenoid sinuses)