Figure 4.
Luciferase expression by cultured SCC-VII cells expressing luciferase driven by a STAT3-responsive promoter, after treatment with STAT3 decoy relative to expression after treatment with mutant decoy for each test condition. STAT3 decoy MB + UTMD treatment reduced luciferase expression by 28% relative to mutant decoy MB + UTMD treatment (p < 0.01), demonstrating inhibition of STAT3 signaling with STAT3 decoy MB + UTMD treatment in vitro.