Table 1.
Overview on diagnostic clinical studies using radiolabeled PSMA ligands for PCa diagnosis and therapy.
| PSMA ligand | Study | Year | Radio-nuclide | Patient no | GSC | Median PSA Level (ng/ml) |
Administered dose (MBq) | Scanning time points | Organs that received the highest dose |
|---|---|---|---|---|---|---|---|---|---|
| MIP-1072, MIP-1095 | Barrett et al. | 2013 | I-123 | 7 | not provided | 121 (mean) | 370 (mean) |
4 h and 24 h p.i. (SPECT/CT) |
123I-MIP-1072: salivary glands: 0.058 urinary bladder wall: 0.092 kidneys: 0.054 123I-MIP-1095: the salivary glands: 0.160 kidneys: 0.110 thyroid: 0.100 (mGy/MBq) |
| MIP-1095 | Zechmann et al. | 2014 | I-124/ I-131 |
16 | 7 (median) |
110.5 | 67.4 (mean) | 1, 4, 24, 48, 72 h p.i. (PET/CT) | salivary glands: 3.76 ± 2.29 liver: 1.66 ± 0.61 kidneys: 1.39 ± 0.56 (mSv/MBq) |
| MIP-1404 MIP-1405 |
Vallabhajosula et al. | 2014 | Tc-99m | 6 | not provided | 15.8 (mean) | 740 ± 111 MBq |
3-5 h p.i. (SPECT/CT) |
99mTc-MIP-1404: kidneys: 0.0733 salivary glands: 0.0524 spleen: 0.0218 99mTc-MIP-1405: urinary bladder wall: 0.0434 kidneys: 0.0363 salivary glands: 0.0301 (mGy/MBq) |
| Glu-NH-CO-NH-Lys(Ahx)-HBED-CC | Afshar-Oromieh et al. | 2013 | Ga-68 | 37 | 7 (median) |
3.3 | 121 (median) |
1 and 3 h p.i. (PET/CT) | intense tracer uptake: kidneys and salivary glands, moderate tracer uptake: lacrimal glands, liver, spleen and in small and large bowel (based on SUVmean and SUVmax) |
| Glu-NH-CO-NH-Lys(Ahx)-HBED-CC | Afshar-Oromieh et al. | 2014 | Ga-68 | 20 | 7.6 (mean) |
2.62 | 149 (median) |
1 h p.i. (PET/CT) 3 h p.i. (PET/MRI) |
|
| Glu-NH-CO-NH-Lys(Ahx)-HBED-CC | Afshar-Oromieh et al. | 2014 | Ga-68 | 37 | 7.4 (mean) |
11.1 | 132 (median) |
1 h p.i. (PET/CT) | |
| Glu-NH-CO-NH-Lys(Ahx)-HBED-CC | Afshar-Oromieh et al. | 2015 | Ga-68 | 319 | 7.5 (mean) |
161 | 154 (median) |
45-75 min. p.i. (PET/CT) | |
| Glu-NH-CO-NH-Lys(Ahx)-HBED-CC | Eiber et al. | 2015 | Ga-68 | 248 | 7 (median) |
1.99 | 155.5 (mean) |
47-61 min. p.i. (PET/CT) | |
| DCFBC | Cho et al. | 2012 | F-18 | 5 | 8.2 (mean) |
10.5 | 370 (mean) |
2 h p.i. (PET/CT) | urinary bladder wall: 0.0324 stomach: 0.0302 heart wall: 0.0292 kidneys: 0.0284 (mGy/MBq) |
| DCFPyl | Szabo et al2 | 2015 | F-18 | 9 | 8.2 (mean) |
30.6 | 320.6 (mean) |
2 h p.i. (PET/CT) | kidneys: 0.0945 urinary bladder wall: 0.0864 submandibular glands: 0.0387 (mGy/MBq) |