Fig 4.

Relationship between overall survival and biomarkers in all patients who provided samples for analysis. (A) Association of baseline concentration of circulating tumor cells (CTC) with overall survival. (B-D) Biomarker decreases from baseline to end of cycle 1 of greater than 20% decrease were segregated from patients without a similar decrease. (B) Squamous cell carcinoma antigen (C) cytokeratin 19 fragment antigen 21-1, and (D) placenta growth factor showed strongest association with overall survival. P value was log-rank.