Table 3.

Summary of transcriptome comparison of S. pneumoniae D39 wild-type grown in CDM plus 0.5 mM Ni²⁺ to CDM plus 0 mM Ni²⁺.

Gene taga	Functionb	Ratioc	P-value
SPD0475	CAAX amino terminal protease family protein	5.39	1.48E−11
SPD0526	Fructose-1,6-bisphosphate aldolase, class II	3.07	1.93E−13
SPD0558	Cell wall-associated serine protease, PrtA	9.67	2.92E−13
SPD0738	Cytidine deaminase	21.92	6.05E−07
SPD0888	Adhesion lipoprotein, AdcAII (LmB)	2.07	7.08E−07
SPD0889	Pneumococcal histidine triad protein D, PhtD	2.06	5.81E−10
SPD0890	Pneumococcal histidine triad protein E, PhtE	7.13	2.81E−05
SPD1038	Pneumococcal histidine triad protein A, PhtA	12.54	2.00E−14
SPD1078	L-lactate dehydrogenase	4.21	2.04E−14
SPD1138	Heat shock protein, HtpX	3.61	9.44E−05
SPD1360	Hypothetical protein	7.29	1.15E−10
SPD1402	Non-heme iron-containing ferritin, DpR	2.65	2.10E−11
SPD1461	Manganese ABC transporter, ATP-binding protein, PsaB	11.90	5.33E−15
SPD1462	Manganese ABC transporter, permease protein, PsaC	10.71	5.26E−14
SPD1464	Thiol peroxidase	2.13	8.68E−10
SPD1632	Hypothetical protein	2.32	3.47E−05
SPD1633	Galactose-1-phosphate uridylyl transferase, GalT	2.68	7.81E−06
SPD1634	Galactokinase, GalK	4.13	1.29E−08
SPD1635	Galactose operon repressor, GalR	5.00	4.27E−07
SPD1636	Alcohol dehydrogenase, zinc-containing, AdhB	35.69	0.00E+00
SPD1637	Transcriptional regulator, MerR family	38.25	0.00E+00
SPD1638	Cation efflux system protein, CzcD	77.89	5.55E−15
SPD1651	Iron-compound ABC transporter, ATP-binding protein	−3.91	1.27E−13
SPD1652	Iron-compound ABC transporter, iron-compound-binding protein	−3.73	4.57E−12
SPD1965	Choline binding protein, PcpA	2.80	8.16E−04
SPD1997	Zinc ABC transporter, zinc-binding lipoprotein, AdcA	3.91	1.14E−12
SPD1998	Zinc ABC transporter, permease protein, AdcB	2.00	2.47E−04
SPD1999	Zinc ABC transporter, ATP-binding protein, AdcC	4.17	1.29E−13
SPD2000	adc operon repressor, AdcR	3.88	2.46E−11

^aGene numbers refer to D39 locus tags.

^bD39 annotation/TIGR4 annotation (Hoskins et al., 2001; Lanie et al., 2007).

^cRatios >2.0 or < 2.0 (wild-type + 0.5 mM Ni²⁺/wild-type + 0 mM Ni²⁺).