Table 4.

Summary of transcriptome comparison of S. pneumoniae D39 wild-type with ΔadcR (SS200) grown in CDM with 0.3 mM Ni²⁺.

Gene taga	Functionb	Ratioc	P-value
SPD0126	Pneumococcal surface protein A, PhpA	2.29	1.35E−05
SPD0277	6- phospho-beta-glucosidase, CelA	12.36	2.28E−13
SPD0278	Hypothetical protein	6.67	1.12E−09
SPD0279	PTS system, IIB component, CelB	7.82	3.99E−09
SPD0280	Transcriptional regulator, CelR	10.24	2.71E−12
SPD0281	PTS system, IIA component, CelC	4.80	1.75E−07
SPD0282	Hypothetical protein	6.8	6.87E−10
SPD0283	PTS system, IIC component, CelD	7.10	8.67E−09
SPD0308	ATP-dependent Clp protease, ATP-binding subunit, ClpL	4.21	5.54E−10
SPD0888	Adhesion lipoprotein, AdcAII (LmB)	1.65	3.39E−04
SPD0889	Pneumococcal histidine triad protein D, PhtD	3.51	1.21E−08
SPD0893	Hypothetical protein	3.51	8.62E−07
SPD1038	Pneumococcal histidine triad protein A, PhtA	5.59	8.67E−09
SPD1514	ABC transporter, ATP-binding protein	−3.35	4.04E−08
SPD1515	Hypothetical protein	−4.06	4.50E−09
SPD1516	Hypothetical protein	−4.57	3.25E−09
SPD1997	Zinc ABC transporter, zinc-binding lipoprotein, AdcA	−18.45	4.07E−13
SPD1998	Zinc ABC transporter, permease protein, AdcB	−2.71	1.29E−04
SPD1999	Zinc ABC transporter, ATP-binding protein, AdcC	−10.76	3.21E−12
SPD2000	adc operon repressor, AdcR	−15.29	7.99E−11
SPD2001	Hypothetical protein	−25.05	1.31E−12

^aGene numbers refer to D39 locus tags.

^bD39 annotation/TIGR4 annotation (Hoskins et al., 2001; Lanie et al., 2007).

^cRatios >2.0 or < 2.0 (SS200+0.3 mM Ni²⁺/wild-type + 0.3 mM Ni²⁺).