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IκBα is a target gene of miR-381. (a) Bioinformatics predictions indicate the potential binding sites of miR-381 in the 3′UTR of IκBα. (b) The luciferase activity significantly decreased in cells cotransfected with pmirGLO-IκBα-3′UTR and miR-381 mimics. (c) The overexpression of miR-381 decreased the protein level of IκBα. (d) The inhibition of miR-381 increased the expression of IκBα. n = 3 independent experiments. ∗ P < 0.05, ∗∗ P < 0.01.
