Fig. 1.

Overview of the patient profile construction and validation processes. The mutation profiles are represented as a binary vector in which each entry indicates a binary state of a gene. The GO-based mutation profile matrix, X, is obtained by multiplying the mutation profile matrix, S, and the gene function profile matrix, G. The ONMF mutation profile matrix, W, is obtained by factorizing GO-MPs through ONMF. For stratification, we assign the patients to the cluster that has the highest value based on the encoding vector. For query search, the query profile is generated by minimizing reconstruction error between the mutation profile and the estimated profile multiplied by latent basis vector, and patients who are similar to a given query patient are identified by calculating the Euclidean distance between them and the query patient