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. 2015 Sep 8;2:29. doi: 10.3389/fvets.2015.00029

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Copyright © 2015 Strain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of MITF function in the nucleus of a melanosome to activate melanin synthesis and secretion and melanocyte growth and survival. The promoter region of MITF can be modified by PAX3, SOX10, TCF, LEF-1, and CREB; TCF and LEF-1 are activated by β catenin from Wnt activation of the FZD receptor and CREB is activated by cAMP from MC1R activation by αMSH. EDNRB, activated by Edn3 and KIT activated by KITLG, act on the MAPK pathway to influence posttranslational Mitf function. Modified from Price and Fisher (63).