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| enzymesresource | Substrate |
Ki (μM)/inhibition type |
||
|---|---|---|---|---|
| Imatinib | Lapatinib | Vandetanib | ||
| UGT1A1 | 4-MU | 19.1 ± 2.8/competitive | 0.5 ± 0.1/competitive | – |
| UGT1A1 | SN-38 | – | 0.6 ± 0.1/competitive | – |
| UGT1A4 | TFP | – | 36.4 ± 5.0/mixed | – |
| UGT1A7 | 4-MU | – | 4.5 ± 0.5/noncompetitive | – |
| UGT1A9 | 4-MU | – | – | 9.0 ± 1.2/mixed |
| UGT2B17 | 4-MU | 0.4 ± 0.1/competitive | – | – |
| HLMs | SN-38 | – | 1.6 ± 0.2/noncompetitive | – |
