Table 4.
Kinetic growth of MDLN cultures and several T cell subsets. n = 14.
| MDLN | CD4 | CD8 | CD4/CD8 ratio | % CD4+Tim3+PD-1+ | % CD4+FoxP3+ * | % CD4+CD25+FoxP3+ * | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Cell number/million | Expansion rate | Cell number/million | Expansion rate | Cell number/million | Expansion rate | |||||
| Day-0 | 12 ± 2.1 | n.a. | 4.8 ± 1.9 | n.a. | 3.6 ± 1.6 | n.a. | 1.3 ± 0.7 | 0.9 % ± 0.6% | 3.2 % ± 3.3% | 0.5 % ± 0.3% |
| Day-7 | 108 ± 16 | 9.0 | 43.2 ± 3.5 | 9.0 | 21.6 ± 2.9 | 6 | 2.0 ± 0.5 | 2.3 % ± 1.2% | 5.9 % ± 1.8% | 0.6 % ± 0.1% |
| Day-11 | 710 ± 24 | 59.2 | 426 ± 31 | 88.45 | 178 ± 21 | 55.0 | 2.4 ± 0.5 | 3.5 % ± 2.2% | 4.6 % ± 3.1% | 0.4 % ± 0.3% |
| Day-14 | 1420 ±110 | 118.3 | 890 ± 45 | 185.4 | 286 ± 29 | 79.4 | 3.2 ± 1.6 | 4.1% ± 1.0% | 4.4% ± 3.3% | 0.7% ± 0.2% |
*
n = 6.