Table 3.
Effects of chemical lesion of the DRN or MRN raphe nuclei on hormonal concentrations (Mean ± S.E.M.)
| Age at sacrifice | Group | n | FSH (ng/ml of serum) |
LH (ng/ml of serum) |
Progesterone (ng/ml of serum) |
Testosterone (ng/ml of serum) |
|---|---|---|---|---|---|---|
| 45 Days | ||||||
| Control | 16 | 10.1 ± 0.66 | 0.57 ± 0.06 | 16.6 ± 1.9 | 0.97 ± 0.14 | |
| Sham DRN | 20 | 8.7 ± 0.30 | 0.37 ± 0.05 | 12.5 ± 0.91 | 0.68 ± 0.10 | |
| Lesion DRN | 14 | 5.9 ± 0.87a,b | 0.33 ± 0.06 | 10.8 ± 1.2 | 0.65 ± 0.09 | |
| Sham MRN | 11 | 9.6 ± 0.35 | 0.68 ± 0.06 | 12.4 ± 2.1 | 0.82 ± 0.17 | |
| Lesion MRN | 10 | 8.6 ± 0.56 | 0.59 ± 0.08 | 9.2 ± 2.9 | 0.97 ± 0.15 | |
| 65 Days | ||||||
| Control | 22 | 8.7 ± 0.38 | 0.58 ± 0.03 | 8.0 ± 1.1 | 2.43 ± 0.24 | |
| Sham DRN | 20 | 8.2 ± 0.30 | 0.60 ± 0.04 | 9.5 ± 1.3 | 2.47 ± 0.11 | |
| Lesion DRN | 22 | 5.4 ± 0.35a,b | 0.42 ± 0.07 | 7.6 ± 1.5 | 1.71 ± 0.11 | |
| Sham MRN | 10 | 6.1 ± 0.38 | 0.75 ± 0.05 | 4.6 ± 0.8 | 2.40 ± 0.37 | |
| Lesion MRN | 15 | 6.3 ± 0.28 | 0.75 ± 0.03 | 4.2 ± 0.5 | 1.54 ± 0.31 | |
Mean ± s.e.m; Sham; sham operation; DRN, dorsal raphe nucleus; MRN, medial raphe nucleus
a p < 0.05 vs. Control group (two-way ANOVA followed by Tukey's test)
b p < 0.05 vs. Sham DRN (two-way ANOVA followed by Tukey's test)