Table 3.
Ten prioritised (highest-scoring) kinase targets in Haemonchus contortus, and three predicted novel targets
| H. contortus kinase identifier | Closest C. elegans homolog | Description [90] | Classification | Score | Number of associated compounds in DrugBank/Kinase SARfari |
|---|---|---|---|---|---|
| Hc-PK-358.1 | CSK-1 | C-terminal Src kinase | TK/CSK | 8 | 12/735 |
| Hc-PK-062.1 | CDK-12 | Cyclin-dependent kinase | CMGC/CDK/CRK7 | 7.5 | 17/0 |
| Hc-PK-063.1 | CDK-5 | Cyclin-dependent kinase | CMGC/CDK/CDK5 | 7.5 | 7/655 |
| Hc-PK-236.1 | CDK-9 | Cyclin-dependent kinase | CMGC/CDK/CDK9 | 7.5 | 1/655 |
| Hc-PK-197.1 | SEK-1 | SAPK/ERK kinase | STE/STE7/MEK3 | 7.5 | 10/0 |
| Hc-PK-263.1 | WTS-1 | WarTS (Drosophila) protein kinase homolog | AGC/NDR/LATS | 7 | 4/0 |
| Hc-PK-002.1 | CDK-7 | Cyclin-dependent kinase | CMGC/CDK/CDK7 | 7 | 2/0 |
| Hc-PK-199.1 | GSK-3 | Glycogen synthase kinase | CMGC/GSK | 7 | 19/1 |
| Hc-PK-210.1 | LIT-1 | “Loss of intestine”; serine - threonine protein kinase | CMGC/MAPK/NMO | 7 | 14/0 |
| Hc-PK-261.1 | DLK-1 | Dual-leucine zipper kinase | TKL/MLK/LZK | 7 | 46/0 |
| Hc-PK-165.1* | CSNK-1 | Casein kinase | CK1/CK1/CK1-G | 4.5 | 3/0 |
| Hc-PK-092.1* | RSKS-1 | Ribosomal protein S6 kinase | AGC/RSK/RSKP70 | 4 | 4/0 |
| Hc-PK-262.1* | CHK-2 | Checkpoint kinase | CAMK/RAD53 | 4 | 1/0 |
The table shows the closest homolog in Caenorhabditis elegans, kinase classification, score and number of associated small-molecule compounds in the DrugBank and/or Kinase SARfari databases for each target. Predicted novel targets are marked (*). Individual compound codes can be accessed in Additional file 1: Tables S3 and S4