Table 6.
Predictors of ICU and hospital mortality stratified by risk (multivariate logistic regression analysis)
| Variable | Adjusted odds ratio (95 % CI) | P-value |
|---|---|---|
| Risk 1: age ˂60 years, normal kidney function (MDRD ˃90), normal liver function (MELD ˂8) | ||
| ICU mortality | ||
| CPOE protocol | 0.82 (0.12–5.63) | 0.84 |
| Revised CPOE protocol | 0.45 (0.07–2.99) | 0.41 |
| APACHE II | 1.22 (1.07–1.38) | 0.002 |
| Hospital mortality | ||
| CPOE protocol | 0.67 (0.13–3.48) | 0.63 |
| Revised CPOE protocol | 0.21 (0.04–1.16) | 0.07 |
| APACHE II | 1.13 (1.00–1.28) | 0.0492 |
| GCS | 0.87 (0.73–1.03) | 0.11 |
| Risk 2: age = 60–70 years, moderate kidney function impairment (MDRD = 30–90), moderate liver function impairment (MELD = 8–14) | ||
| ICU mortality | ||
| CPOE protocol | 0.54 (0.06–4.82) | 0.58 |
| Revised CPOE protocol | 1.43 (0.15–13.88) | 0.76 |
| GCS | 1.47 (0.99–2.18) | 0.06 |
| Hospital mortality | ||
| CPOE protocol | 0.59 (0.09–4.01) | 0.59 |
| Revised CPOE protocol | 1.15 (0.198–6.74) | 0.87 |
| Risk 3: age ˃70 years, severe kidney function impairment (MDRD ˂30), severe liver function impairment (MELD ˃14) | ||
| ICU mortality | ||
| CPOE protocol | 2.64 (1.03–6.56) | 0.04 |
| Revised CPOE protocol | 0.68 (0.24–1.88) | 0.45 |
| Chronic cardiovascular disease | 2.07 (0.81–5.30) | 0.13 |
| Chronic liver disease | 5.87 (1.99–17.27) | 0.001 |
| APACHE II | 1.11 (1.05–1.18) | 0.0002 |
| Hospital mortality | ||
| CPOE protocol | 1.43 (0.59–3.46) | 0.43 |
| Revised CPOE protocol | 1.11 (0.44–2.79) | 0.82 |
| Chronic liver disease | 3.25 (1.07–9.84) | 0.04 |
| APACHE II | 1.12 (1.06–1.19) | <0.0001 |
APACHE Acute Physiology and Chronic Health Evaluation, CPOE computerized physician order entry, ICU intensive care unit, GCS Glasgow Coma Scale, MDRD Modification of Diet in Renal Disease (surrogate for kidney function), MELD Model for End-Stage Liver Disease (surrogate for liver function)