Table 2.
Parameters
| Parameter | Name | Value used in simulations |
|---|---|---|
| Δ t | Time interval | 0.1 s |
| d | Width of grid (grid spacing) | 10 μm |
| D 1track | Expected value of the absorbed dose given by one radiation track | 0.001 Gy |
| K a | Average number of radiation tracks passing through a grid over Δ t | 1,000 track/min |
| M w | Diffusion constants of virtual signals through the MDP | 1.0×10−10 m 2/s |
| M α | Signal-production constant of virtual signals through the MDP | 1 unit/Gy |
| M β | Decay constant of virtual signals through the MDP | 4.6×10−6 s −1 |
| G w | Diffusion constants of virtual signals through the GJP | 5.0×10−11 m 2/s |
| G α | Signal-production constant of virtual signals through the GJP | 1 unit/Gy |
| G β | Decay constant of virtual signals through the GJP | 1.18×10−3 s −1 |
| ZR λ i,j | DSB induction coefficients for radiation | G0 or G1 phase |
| AV: 40; SD: 22 DSBs/Gy | ||
| S phase | ||
| AV: 80; SD: 24 DSBs/Gy | ||
| G2 phase | ||
| AV: 80; SD: 26 DSBs/Gy | ||
| M1 or M2 phase | ||
| AV: 80; SD: 16 DSBs/Gy | ||
| ZM λ i,j | DSB induction coefficients for virtual signals through the MDP | G0 or G1 phase |
| AV: 6.0×10−3; SD: 1.0×10−2 DSBs/unit/s | ||
| S, G2, M1, or M2 phase | ||
| AV: 1.2×10−2; SD: 1.0×10−2 DSBs/unit/s | ||
| ZG λ i,j | DSB induction coefficients for virtual signals through the GJP | G0 or G1 phase |
| AV: 6.0×10−2; SD: 1.0×10−2 DSBs/unit/s | ||
| S, G2, M1, or M2 phase | ||
| AV: 1.2×10−1; SD: 1.0×10−2 DSBs/unit/s | ||
| ZB λ i,j | DSB induction coefficients for background factors | G0 or G1 phase |
| AV: 1.4×10−5; SD: 0 DSBs/s | ||
| S, G2, M1, or M2 phase | ||
| AV: 2.8×10−5; SD: 0 DSBs/s | ||
| Zr λ i,j | Probability of DSB repair | G0 or G1 phase |
| AV: 9.33×10−7; SD: 2.0×10−5 s −1 | ||
| S, G2, M1, or M2 phase | ||
| AV: 7.45×10−7; SD: 2.0×10−5 s −1 | ||
| A H i,j | Thresholds for transition between cell-cycle progression and cell-cycle arrest | G1/S checkpoint |
| AV: 5; SD: 1 DSBs | ||
| S/G2 checkpoint | ||
| AV: 40; SD: 8 DSBs | ||
| G2/M1 checkpoint | ||
| AV: 20; SD: 4 DSBs | ||
| M1/M2 checkpoint | ||
| AV: 40; SD: 8 DSBs | ||
| p−RD H i,j | Thresholds for transition from the PR to the p-RD state | G0 or G1 phase |
| AV: 93; SD: 38 DSBs | ||
| S phase | ||
| AV: 42; SD: 144 DSBs | ||
| G2 phase | ||
| AV: 116; SD: 124 DSBs | ||
| M1 or M2 phase | ||
| AV: 22; SD: 91 DSBs | ||
| p−ID H i,j | Thresholds for transition from the PR to the p-ID state | G0 or G1 phase |
| AV: 186; SD: 38 DSBs | ||
| S phase | ||
| AV: 84; SD: 144 DSBs | ||
| G2 phase | ||
| AV: 232; SD: 124 DSBs | ||
| M1 or M2 phase | ||
| AV: 44; SD: 91 DSBs | ||
| T c | Period of each phase of the cell cycle | G1 phase |
| AV: 11; SD: 2.2 h | ||
| S phase | ||
| AV: 8; SD: 1.6 h | ||
| G2 phase | ||
| AV: 4; SD: 0.8 h | ||
| M1 or M2 phase | ||
| AV: 0.5; SD: 0.1 h |
AV: average; SD: standard deviation