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. 2015 Dec 8;2:150068. doi: 10.1038/sdata.2015.68

Figure 1. Scheme of experiments for multi-omics comparison of steatosis grades.

Figure 1

The scheme shows how the distinct severities of non-alcoholic fatty liver disease (NAFLD) are compared in terms of transcriptomics, metabolomics and potentially relevant parts of the proteome. Liver biopsies were taken from NAFLD patients and classified by pathologists as low-grade (5–33% steatosis area) and high-grade (>33% steatosis area). The transcriptome of liver biopsies were assessed on Illumina HumanHT-12 v4 BeadChips and on RT-PCR. Serum samples of these NAFLD patients and from healthy persons were taken and investigated at the protein level employing ELISA assays and at the metabolome level via Nuclear Magnetic Resonance (NMR).