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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: J Neurochem. 2014 Apr 2;130(1):115–125. doi: 10.1111/jnc.12706

Fig. 2.

Fig. 2

(A) Aβ plaque (4G8) and tau tangle (AT8) immunoreactivity in the hippocampi of 21 month female 3xTg Alzheimer’s disease (AD) mice. Images were captured at 10× magnification; scale bar distance shows 100 μm. (B) Ovariectomy is associated with increased hippocampal Aβ plaques that are not reduced by LA treatment or E2 replacement in 21-month 3xTg AD mice. Bars with SE show the area fraction of 4G8 staining for Aβ plaques in equivalent regions of the hippocampus. (C) Ovariectomy is associated with increased phosphorylated tau in the hippocampi of 21 month 3xTg AD mice and tau load is further elevated by E2 replacement. Bars with SE show the area fraction of AT8 staining for phosphorylated tau in equivalent regions of the hippocampus. Significant difference (p ≤ 0.05) from SHAM (a), from OVX+SAL (b), from OVX+LA (c), from OVX+E2 (d).