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. Author manuscript; available in PMC: 2016 Oct 20.
Published in final edited form as: Immunity. 2015 Oct 20;43(4):715–726. doi: 10.1016/j.immuni.2015.10.005

Figure 6. TRIM62 Regulates Immune Responses and Susceptibility to Candida albicans Infection In Vivo.

Figure 6

(A) WT and Trim62−/− mice were injected i.v. with heat-killed C. albicans and serum IL-6 levels were quantified 4 h later by ELISA (n = 5). Bars display IL-6 relative to WT levels. (B) WT and Trim62−/− mice were injected with C. albicans and fungal loads in kidney, spleen, and liver were assessed at 3 and 6 days post-infection. (C) WT and Trim62−/− BMDMs were incubated with pHrodo-labeled C. albicans, and phagocytosed C. albicans was quantified by intracellular fluorescence via flow cytometry. (D) Survival curve showing percent survival over time in WT and Trim62−/− mice infected with C. albicans. Bars represent means ± s.d. *P < 0.05. See also Figure S6.