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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Alzheimers Dement. 2014 Dec 20;11(6):658–671. doi: 10.1016/j.jalz.2014.05.1757

Figure 1. The pathways highlighted by ALIGATOR ontology analyses are related.

Figure 1

The network was generated in ReVIGO[32] using gene ontology processes identified in ALIGATOR only. Bubble size (and label font size) reflects the frequency of the GO term in the GOA database, bubble colour reflects pathway p-value. Similar GO terms are linked by edges (lines) in the network where line width reflects the degree of similarity between pathways but line length is arbitrary. Strong relationships are revealed between negative regulation of endocytosis and cholesterol transport and many of the pathways are related to the immune response process.