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. Author manuscript; available in PMC: 2016 Oct 19.
Published in final edited form as: Brain Res Bull. 2015 Oct 19;119(0 0):41–51. doi: 10.1016/j.brainresbull.2015.10.005

Figure 1.

Figure 1

Postnatal day 30 CamKIIαNampt−/− mice showed impaired induction of long-term depression (LTD) but not long-term potentiation (LTP). A, LTD was not induced by low frequency stimulation (LFS) in CamKIIαNampt−/− mice (white squares), but was induced in control mice (black circles; n=5 each). B, LTP was induced by high frequency stimulation (HFS, arrow) in all CamKIIαNampt−/− and control mice tested (n=5 each). A,B, Traces to the right depict representative field excitatory postsynaptic potentials (fEPSPs) before (dotted lines) and 60 min after HFS or LFS (solid lines). Calibration: 1 mV, 5 ms. C, A frequency response curve for LTD and LTP evoked by 900 pulses delivered at 1, 3, 10, 30, and 100 Hz (n=5). Data are presented as mean ± S.E.M.