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. 2015 Nov 17;112(48):14918–14923. doi: 10.1073/pnas.1507669112

Table S1.

GO enrichment analysis for 1,102 orthogroups belonging to 1to2 category obtained from human-centered analysis

GO ID GO name No. of 1to2 category (1,102) No. of allorthogroups(6,264) Padj*
Overrepresented GO ID
 0005891 Voltage-gated calcium channel complex 12 15 <0.001
 0007215 Glutamate receptor signaling pathway 14 19 <0.001
 0022843 Voltage-gated cation channel activity 26 51 <0.001
 0007156 Homophilic cell adhesion 26 54 <0.001
 0015085 Calcium ion transmembrane transporter activity 29 62 <0.001
 0009581 Detection of external stimulus 31 72 <0.001
 0009582 Detection of abiotic stimulus 31 72 <0.001
 0034703 Cation channel complex 33 65 <0.001
 0007611 Learning or memory 33 77 <0.001
 0045202 Synapse 38 99 <0.001
 0097060 Synaptic membrane 40 99 <0.001
 0005261 Cation channel activity 43 117 <0.001
 0034765 Regulation of ion transmembrane transport 47 126 <0.001
 0034762 Regulation of transmembrane transport 47 127 <0.001
 0043235 Receptor complex 48 123 <0.001
 0034702 Ion channel complex 50 115 <0.001
 0005911 Cell–cell junction 50 123 <0.001
 0022836 Gated channel activity 50 131 <0.001
 1902495 Transmembrane transporter complex 52 122 <0.001
 1990351 Transporter complex 52 122 <0.001
 0016337 Cell–cell adhesion 54 139 <0.001
 0005216 Ion channel activity 58 164 <0.001
 0022838 Substrate-specific channel activity 58 165 <0.001
 0044456 Synapse part 59 163 <0.001
 0015267 Channel activity 61 171 <0.001
 0022803 Passive transmembrane transporter activity 61 171 <0.001
 0050767 Regulation of neurogenesis 66 200 <0.001
 0007268 Synaptic transmission 67 192 <0.001
 0043005 Neuron projection 72 237 <0.001
 0043269 Regulation of ion transport 73 195 <0.001
 0016477 Cell migration 73 238 <0.001
 0060284 Regulation of cell development 75 247 <0.001
 0051960 Regulation of nervous system development 76 226 <0.001
 0048646 Anatomical structure formation involved in morphogenesis 83 271 <0.001
 0007267 Cell–cell signaling 86 285 <0.001
 0005509 Calcium ion binding 87 269 <0.001
 0015075 Ion transmembrane transporter activity 88 302 <0.001
 0051094 Positive regulation of developmental process 89 300 <0.001
 0022891 Substrate-specific transmembrane transporter activity 92 319 <0.001
 0023052 Signaling 93 298 <0.001
 0044700 Single organism signaling 93 298 <0.001
 0050877 Neurological system process 94 284 <0.001
 0007155 Cell adhesion 96 315 <0.001
 0022610 Biological adhesion 96 316 <0.001
 0007154 Cell communication 100 347 <0.001
 0022857 Transmembrane transporter activity 102 356 <0.001
 0055085 Transmembrane transport 115 411 <0.001
 0042995 Cell projection 118 423 <0.001
 0030054 Cell junction 122 354 <0.001
 0097458 Neuron part 122 371 <0.001
 0005887 Integral component of plasma membrane 122 416 <0.001
 0006811 Ion transport 128 452 <0.001
 0006928 Cellular component movement 132 468 <0.001
 2000026 Regulation of multicellular organismal development 133 509 <0.001
 0003008 System process 134 437 <0.001
 0051049 Regulation of transport 136 529 <0.001
 0019899 Enzyme binding 137 531 <0.001
 0004872 Receptor activity 142 554 <0.001
 0050793 Regulation of developmental process 165 659 <0.001
 0032879 Regulation of localization 185 714 <0.001
 0065008 Regulation of biological quality 224 933 <0.001
 0044765 Single-organism transport 230 949 <0.001
 0048856 Anatomical structure development 244 1,002 <0.001
 0044459 Plasma membrane part 249 833 <0.001
 0044707 Single–multicellular-organism process 272 1,098 <0.001
 0032501 Multicellular organismal process 276 1,118 <0.001
 0006810 Transport 287 1,226 <0.001
 0051234 Establishment of localization 300 1,259 <0.001
 0044767 Single-organism developmental process 332 1,412 <0.001
 0032502 Developmental process 362 1,566 <0.001
 0005886 Plasma membrane 364 1,325 <0.001
 0016021 Integral component of membrane 364 1,684 <0.001
 0044425 Membrane part 487 2,182 <0.001
 0016020 Membrane 510 2,212 <0.001
 0005515 Protein binding 605 2,999 <0.001
 0044763 Single-organism cellular process 679 3,285 <0.001
 0065007 Biological regulation 700 3,492 <0.001
 0044699 Single-organism process 771 3,819 <0.001
 0005575 Cellular_component 1,013 5,474 <0.001
 0005245 Voltage-gated calcium channel activity 14 21 0.002
 0048870 Cell motility 75 252 0.002
 0005244 Voltage-gated ion channel activity 30 71 0.003
 0022832 Voltage-gated channel activity 30 71 0.003
 0072509 Divalent inorganic cation transmembrane transporter activity 30 71 0.003
 0050953 Sensory perception of light stimulus 34 86 0.003
 0040011 Locomotion 85 297 0.003
 0051239 Regulation of multicellular organismal process 190 798 0.003
 0007165 Signal transduction 356 1,656 0.003
 0050789 Regulation of biological process 659 3,337 0.003
 0007612 Learning 21 42 0.004
 0007600 Sensory perception 55 169 0.004
 0034220 Ion transmembrane transport 77 264 0.004
 0008092 Cytoskeletal protein binding 93 336 0.004
 0005215 Transporter activity 120 461 0.004
 0050794 Regulation of cellular process 631 3,185 0.004
 0034704 Calcium channel complex 14 22 0.006
 0007601 Visual perception 33 84 0.006
 0050890 Cognition 34 88 0.006
 0005516 Calmodulin binding 35 92 0.006
 0001525 Angiogenesis 38 103 0.006
 0022892 Substrate-specific transporter activity 101 375 0.006
 0045595 Regulation of cell differentiation 121 469 0.006
 0044464 Cell part 922 4,925 0.006
 0051899 Membrane depolarization 18 34 0.007
 0010646 Regulation of cell communication 217 945 0.007
 0008066 Glutamate receptor activity 11 15 0.008
 0005262 Calcium channel activity 23 50 0.008
 0046873 Metal ion transmembrane transporter activity 52 161 0.008
 0022890 Inorganic cation transmembrane transporter activity 55 173 0.008
 0045597 Positive regulation of cell differentiation 66 220 0.008
 0048869 Cellular developmental process 186 789 0.008
 0034330 Cell junction organization 31 79 0.009
 0023051 Regulation of signaling 215 939 0.009
 0009653 Anatomical structure morphogenesis 120 470 0.01
 0050804 Regulation of synaptic transmission 33 87 0.012
 0044708 Single-organism behavior 44 130 0.012
 0016529 Sarcoplasmic reticulum 12 18 0.015
 0048167 Regulation of synaptic plasticity 22 48 0.015
 0045664 Regulation of neuron differentiation 50 156 0.019
 0007610 Behavior 56 181 0.019
 0030001 Metal ion transport 65 220 0.019
 0043167 Ion binding 426 2,064 0.019
 0050770 Regulation of axonogenesis 19 39 0.022
 0050839 Cell adhesion molecule binding 15 27 0.023
 0042391 Regulation of membrane potential 35 97 0.023
 0003674 Molecular_function 937 5,039 0.023
 0019901 Protein kinase binding 55 179 0.024
 0008324 Cation transmembrane transporter activity 66 227 0.024
 0004871 Signal transducer activity 142 584 0.024
 0060089 Molecular transducer activity 142 584 0.024
 0046872 Metal ion binding 286 1,322 0.028
 0030315 T tubule 12 19 0.029
 0008150 Biological_process 964 5,218 0.035
 0045216 Cell–cell junction organization 26 65 0.036
 0044463 Cell projection part 70 249 0.04
 0044449 Contractile fiber part 29 77 0.045
 0019900 Kinase binding 59 201 0.045
 0043169 Cation binding 290 1,353 0.045
 0035637 Multicellular organismal signaling 12 20 0.049
 0051270 Regulation of cellular component movement 65 229 0.049
 0045211 Postsynaptic membrane 29 78 0.05
Underrepresented GO ID
 0006396 RNA processing 12 192 0.006
 0044260 Cellular macromolecule metabolic process 282 1,944 0.022
 0006974 Cellular response to DNA damage stimulus 15 202 0.041
 0034470 ncRNA processing 0 54 0.05
 0005730 Nucleolus 17 215 0.05
*

Adjusted P value from the results of 1,000 simulated null hypothesis queries.