Table 10.

Exploration of heteroaryl groups on phenyl ring of aniline moiety.⁴⁷

Compd	Ar	IC50 (μM)a	Compd	Ar	IC50 (μM)a
89		0.085	99		0.24
90		0.041	100		0.27
91		0.13	101		0.6
92		0.22	102		0.48
93		0.83	103		0.16
94		1.95	104		10
95		0.34	105		0.9
96		0.46	106		0.74
97		0.81	107		0.42
98		0.11	108		0.078

^a50% inhibition of binding of radio ligand [¹²⁵I]PYY at human Y2 receptors.