Skip to main content
. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 11.

Modifications of diethyl amide of phenyl glycine moiety with various heteroaromatics.48

graphic file with name nihms-715437-f0101.jpg
Compd Ar IC50 (μM)a Compd Ar IC50 (μM)a
109 graphic file with name nihms-715437-t0102.jpg 0.24 114 graphic file with name nihms-715437-t0103.jpg 0.29
110 graphic file with name nihms-715437-t0104.jpg 0.027 (7.4)b 115 graphic file with name nihms-715437-t0105.jpg 0.15
111 graphic file with name nihms-715437-t0106.jpg 0.027 (7.45) 116 graphic file with name nihms-715437-t0107.jpg 0.038 (7.5)
112 graphic file with name nihms-715437-t0108.jpg 0.17 117 graphic file with name nihms-715437-t0109.jpg 0.034 (7.2)
113 graphic file with name nihms-715437-t0110.jpg 0.72 118 graphic file with name nihms-715437-t0111.jpg 0.033
a

50% inhibition of binding of radio ligand [125I]PYY at human Y2 receptors.