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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 12.

SAR data of anilide analogs.52

graphic file with name nihms-715437-f0112.jpg
Compd R fpKia Solubility (μg/mL) Compd R fpKi Solubility (μg/mL)
121(hit) graphic file with name nihms-715437-t0113.jpg 5.6 113 127 graphic file with name nihms-715437-t0114.jpg 7.1 3
122 graphic file with name nihms-715437-t0115.jpg 7.3 22 128 graphic file with name nihms-715437-t0116.jpg 8.0 0
123 graphic file with name nihms-715437-t0117.jpg 6.8 4 129 graphic file with name nihms-715437-t0118.jpg 8.3 0
124 graphic file with name nihms-715437-t0119.jpg 7.7 4 130 graphic file with name nihms-715437-t0120.jpg 8.2 7
125 graphic file with name nihms-715437-t0121.jpg 6.5 nt 131 graphic file with name nihms-715437-t0122.jpg 6.5 70
126 graphic file with name nihms-715437-t0123.jpg 5.2 nt (±)132 graphic file with name nihms-715437-t0124.jpg 7.9 8
a

Functional activity against human Y2 receptors using [35S]GTPγS binding assay.