Table 18.

SAR and functional activity data of the thiourea analogs.⁵⁴

Compd	R	IC50a (μM)	Compd	R	IC50a (μM)
SF-11	4-OC2H5	0.199	158	4-CON(C2H5)2	0.078
150	-H	NAc	159	4-SO2N(CH3)2	0.019
151	4-OCH3	1.1	160	4-SO2N(C2H5)2	0.136
152	4-OiPr	1.77	161	3-OCH3	8.162b
153	4-OCF3	1.047	162	3- COOC2H5	0.238b
154	4-nC3H7	0.777	163	3-Cl, 4-N(C2H5)2	0.085
155	4-N(C2H5)2	0.072b	164	3-CN, 4-OC2H5	0.323
156	4-COOC2H5	0.207	165	2-CH3, 4- OC2H5	NA
157	4-CON(CH3)2	0.301	166	2-F, 4- OC2H5	1.35

^aFunctional activity using cAMP biosensor assy. All compounds were inactive at the NPY Y1 receptor

^bexhibited partial antagonism

^cnot active (NA) at the highest concentration tested (10 μM).