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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 19.

SAR exploration of the diphenylcarbinol moiety.54

graphic file with name nihms-715437-f0140.jpg
Compd R X R1 Y2 IC50a (μM)
167 graphic file with name nihms-715437-t0141.jpg CH OC2H5 NAb
168 graphic file with name nihms-715437-t0142.jpg CH OC2H5 NA
169 graphic file with name nihms-715437-t0143.jpg CH SO2N(CH3)2 NA
170 graphic file with name nihms-715437-t0144.jpg N SO2N(CH3)2 0.483
171 graphic file with name nihms-715437-t0145.jpg CH OC2H5 NA
172 graphic file with name nihms-715437-t0146.jpg CH SO2N(CH3)2 0.098
173 graphic file with name nihms-715437-t0147.jpg CH SO2N(CH3)2 NA
174 graphic file with name nihms-715437-t0148.jpg CH SO2N(CH3)2 0.248
175 graphic file with name nihms-715437-t0149.jpg CH SO2N(CH3)2 NA
176 graphic file with name nihms-715437-t0150.jpg CH OC2H5 3.3
177 graphic file with name nihms-715437-t0151.jpg CH SO2N(CH3)2 0.089
a

See footnote of Table 18.

b

See footnote of Table 18.