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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 21.

Functional and binding affinity data of PYY (3-36) and its truncated analogs.58-60, 64

Compd Peptidea Y2 EC50 (nM) Y2 Ki (nM) Y1 Ki (nM) Y5 Ki (nM)
186 PYY (3-36) 0.3 0.4 21 20
187 PYY (22-36) 11 3 390 >1000
188 PYY (25-36) 240 270 >1000 >1000
189 AcPYY (22-36) 13 9 118 >1000
190 AcPYY (24-36)-L31 6 5 210 >1000
191 AcPYY (25-36) 27 30 >1000 >1000
192 graphic file with name nihms-715437-t0153.jpg 3 4 >1000 >1000
193 graphic file with name nihms-715437-t0154.jpg 4 11 >1000 >1000
194 graphic file with name nihms-715437-t0155.jpg 6 7 >1000 >1000
195 graphic file with name nihms-715437-t0156.jpg 25 41 4000 1600
196 graphic file with name nihms-715437-t0157.jpg 6.5 9.1 760 630
197 (Ahx5-24)NPYb 9 5 100 >1000
198 Ac-YKK(Kp)(Ahx5-24)ANPYc nd 26.1 nd nd
a

All peptides are amidated at the C-terminal. PYY(25-36)-L31 or PYY(24-36)-L31 are peptides in which Val 31 of corresponding PYY peptide is replaced with Leu.

b

5-24 amino acid residues of NPY are replaced with 6-aminohexanoic acid.

c

Kp is Nε-palmitoyl-L-lysine.

nd: not determined.