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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 3.

SAR exploration of the cinnamide moiety.41

graphic file with name nihms-715437-f0033.jpg
Compd R IC50 (μM)a Compd R IC50 (μM)a
19 graphic file with name nihms-715437-t0034.jpg 18 25 graphic file with name nihms-715437-t0035.jpg 2.8
20 graphic file with name nihms-715437-t0036.jpg 30 26 graphic file with name nihms-715437-t0037.jpg 30
21 graphic file with name nihms-715437-t0038.jpg 30 27 graphic file with name nihms-715437-t0039.jpg 30
22 graphic file with name nihms-715437-t0040.jpg 11 28 graphic file with name nihms-715437-t0041.jpg 12
23 graphic file with name nihms-715437-t0042.jpg 22 29 graphic file with name nihms-715437-t0043.jpg 17
24 graphic file with name nihms-715437-t0044.jpg 9.2 30 graphic file with name nihms-715437-t0045.jpg 3.2
a

50% inhibition of binding of radio ligand [125I]PYY at human Y2 receptors.