Skip to main content
. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 4.

Exploration of substitution on the phenyl ring of the cinnamide moiety.41

graphic file with name nihms-715437-f0046.jpg
Compd R IC50 (μM)a Compd R IC50 (μM)a
31 3-F 3.6 37 3-CF3 8.9
32 3-Cl 3.0 38 4-Cl 3.6
33 3-CH3 1.4 39 4-CF3 2.8
34 3-CN 1.0 40 3,5-diF 2.5
35 3-Br 3.3 41 3,5-diCH3 3.9
36 3-NO2 1.9 42 3,5-diCl 30
a

50% inhibition of binding of radio ligand [125I]PYY at human Y2 receptors.