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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 6.

SAR and binding affinity data of arylpiperazine analogs.43

graphic file with name nihms-715437-f0048.jpg
Compd R1 R2 R3 IC50 (μM)a
49 COOCH3 H graphic file with name nihms-715437-t0049.jpg 0.24
50 COOCH3 H graphic file with name nihms-715437-t0050.jpg 0.22
51 COOCH3 H graphic file with name nihms-715437-t0051.jpg 0.53
52 COOCH3 CN graphic file with name nihms-715437-t0052.jpg 0.025
53 COOCH3 CH3 graphic file with name nihms-715437-t0053.jpg 0.100
54 COOCH3 F graphic file with name nihms-715437-t0054.jpg 0.052
55 CONHC2H5 F graphic file with name nihms-715437-t0055.jpg 0.042
56 (JNJ 31020028) CON(C2H5)2 F graphic file with name nihms-715437-t0056.jpg 0.006
a

50% inhibition of binding of radio ligand [125I]PYY at human Y2 receptors.