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. Author manuscript; available in PMC: 2015 Dec 8.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Dec 4;24(2):430–441. doi: 10.1016/j.bmcl.2013.11.061

Table 8.

Exploration of substitution on the phenyl ring of the phenyl glycine moiety.44

graphic file with name nihms-715437-f0072.jpg
Compd R IC50 (μM)a Compd R IC50 (μM)a
71 3-F 0.033 77 4-OCH3 0.018
72 3-Cl 0.05 78 4-OC2H5 0.044
73 3-OCH3 0.04 79 4-OCF3 0.026
74 4-F 0.2 80 4-OH 0.1
75 4-Cl 0.1 81 3,4-diF 0.33
76 4-CN 0.044 82 2,4-diF 0.15
a

50% inhibition of binding of radio ligand [125I]PYY at human Y2 receptors.