Fig. 2.

Mean arterial pressure (MAP) of C57BL/6 and ApoE^−/− mice treated chronically or acutely with AICAR. MAP was measured by cannulation of the left common carotid artery. (A) ApoE^−/− mice were fed high fat diet for a total of 6 weeks with vehicle or AICAR injected daily for the final 2 weeks. C57BL/6 mice received chow diet and either vehicle or AICAR. **p < 0.01, ***p < 0.001; n = 6–10. (B) MAP of ApoE^−/− mice on high fat diet for 12 weeks and age-matched C57BL/6 controls administrated vehicle or AICAR 45 min before blood pressure measurement. **p < 0.01; n = 6–10.