Fig. 6.

Effect of preincubation of AMPK activating agents on the constrictor response to U46619 in mouse aortae. (A) 2 mM AICAR or 30 μM A769662 were added for 45 min prior to U46619 contraction in 3 month fat-fed ApoE^−/− mice and aged-matched C57BL/6 mice. ***p < 0.001; ^†p < 0.05 vs. C57BL/6 AICAR; n = 4–9. (B) 2 mM AICAR or 30 μM A769662 were added for 45 min prior to U46619 contraction in AMPKα1^−/− mice and their wild-type littermates (S129). *p < 0.05, ***p < 0.001; n = 4–6.