Table 2.

Weight and hemodynamic measurements after acute AICAR administration in C57BL/6 and 12 week fat-fed ApoE^−/− mice.

	C57BL/6 mice (12 weeks age matched)		ApoE −/− mice (12 weeks high fat diet)
Vehicle	AICAR	Vehicle	AICAR
Body weight (g)	26.7 ± 0.7		30.2 ± 0.8⁎⁎
Heart weight (%)	0.69 ± 0.04		0.67 ± 0.06
Liver weight (%)	5.42 ± 0.11		4.09 ± 0.2⁎⁎⁎
Spleen weight (%)	0.27 ± 0.02		0.55 ± 0.07⁎⁎
MAP (mm Hg)	94.3 ± 1.6	83.2 ± 1.8⁎	112.3 ± 3.5⁎⁎⁎	102.3 ± 2.9††
DAP (mm Hg)	79.2 ± 2.3	64.1 ± 1.9⁎⁎	107.4 ± 2.1⁎⁎⁎	98.0 ± 1.1†
SAP (mm Hg)	109.5 ± 2.5	103.9 ± 3.09	117.8 ± 2.3⁎	106.3 ± 3.7†
PP (mm Hg)	31.0 ± 0.8	39.6 ± 2.2	10.4 ± 3.0	8.3 ± 2.6
HR (bpm)	440.1 ± 7.5	400.4 ± 21.2⁎	486.7 ± 16.7⁎	350.1 ± 30†

Organ weight was taken as a percentage of the body weight. MAP, HR, DAP, SAP and PP were calculated from the blood pressure trace. n = 6–10.

^⁎p < 0.05.

^⁎⁎p < 0.01.

^⁎⁎⁎p < 0.001 vs. C57BL/6 vehicle.

^†p < 0.05.

^††p < 0.01 vs. ApoE^−/− vehicle.