Table 2.

Clinical outcomes

	Standard group (n=308)	Modified group (n=307)	Median difference*	HR estimate†	p value
Time to resolution cough (days)‡	15·0 (10·0 to 42·5); n=296	15·0 (10·0 to 41·0); n=293	1·00 (−1·0 to 2·0)	..	..
Time feeding returned to ≥75% normal (h)§	24·1 (6·5 to 62·1); n=304	19·5 (6·3 to 47·2); n=296	2·7 (−0·3 to 7·3)	..	..
Time back to normal (days)¶	12·0 (7·0 to 25·0); n=296	11·0 (6·0 to 20·0); n=293	1·0 (0 to 3·0)	..	..
Time to fit to discharge (h)	44·2 (18·6 to 87·5); n=283	30·2 (15·6 to 59·7); n=276	..	1·46 (1·23 to 1·73)	<0·0001
Time to actual discharge (h)	50·9 (23·1 to 93·4); n=303	40·9 (21·8 to 67·3); n=301	..	1·28 (1·09 to 1·50)	0·003
Time to no further supplemental oxygen (h)	27·6 (0 to 68·1); n=305	5·7 (0 to 32·4); n=304	..	1·37 (1·12 to 1·68)	0·0021

Data are median (IQR); n or estimate of difference (95% CI), unless otherwise stated.

^*Median difference is standard–modified (<0 indicates benefit to standard practice).

^†HR is standard/modified (<1 indicates benefit to standard practice).

^‡Equivalence defined as plus or minus 2 days.

^§Equivalence defined as plus or minus 4 h.

^¶Equivalence defined as plus or minus 2 days.