Figure 4.

Assessment of DNA from bronchial brushings in the placebo (n=7) and pGM169/GL67A (n=14) subgroups (A) and the response of the bronchial epithelium to perfusion with a zero chloride solution containing isoprenaline 10 μM (B, C)

Horizontal bars show median values. Each circle in panel A represents an individual patient. Each symbol in panels B and C shows the change in response from trial start to finish for the relevant treatment in an individual patient. Of the 16 participants in the bronchoscopy subgroup, 15 individuals had post-dose bronchoscopies, of whom 14 individuals generated samples for DNA and mRNA molecular analysis. The plotted value in panel B is the mean of all interpretable recordings (range 1–3), and in panel C is the most negative value obtained from all interpretable recordings, at each timepoint for that patient. A more negative value is in the non-cystic fibrosis direction. LOQ=limit of quantification, PBNQ=positive but not quantifiable.