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. 2015 Dec 8;351:h6138. doi: 10.1136/bmj.h6138

Table 2 .

Correlates of increased frequency of HbA1c testing

Excessive HbA1c testing Frequent HbA1c testing
Odds ratio (95% CI) P Odds ratio (95% CI) P
Patient age (years)
 18-44 Ref Ref Ref Ref
 45-54 0.94 (0.85 to 1.05) 0.29 0.97 (0.93 to 1.02) 0.23
 55-64 1.08 (0.98, 1.19) 0.10 1.07 (1.03 to 1.12) <0.001
 65-74 1.17 (1.03 to 1.32) 0.01 1.12 (1.06 to 1.19) <0.001
 ≥75 1.10 (0.95 to 1.27) 0.21 1.07 (1.00 to 1.15) 0.05
Sex
 Male Ref Ref Ref Ref
 Female 0.95 (0.89 to 1.02) 0.13 0.98 (0.96 to 1.01) 0.22
Race
 White Ref Ref Ref Ref
 Non-white 0.99 (0.93 to 1.04) 0.64 0.99 (0.97 to 1.01) 0.40
US census region
 South Ref Ref Ref Ref
 Midwest 0.67 (0.58 to 0.79) <0.001 0.95 (0.90 to 1.01) 0.12
 Northeast 1.60 (1.44 to 1.78) <0.001 1.14 (1.08 to 1.19) <0.001
 West 1.01 (0.86 to 1.18) 0.93 0.90 (0.84 to 0.97) 0.004
Year of index HbA1c test
 2001-02 Ref Ref Ref Ref
 2003-04 0.95 (0.78 to 1.16) 0.61 0.93 (0.85 to 1.01) 0.09
 2005-06 0.97 (0.83 to 1.14) 0.73 0.86 (0.80 to 0.92) <0.001
 2007-08 1.11 (0.99 to 1.24) 0.08 1.10 (1.05 to 1.16) <0.001
 2009-10 0.74 (0.67 to 0.83) <0.001 0.85 (0.80 to 0.89) <0.001
 2011 0.54 (0.46 to 0.64) <0.001 0.77 (0.72 to 0.83) <0.001
Index HbA1c
 ≤5.6% Ref Ref Ref Ref
 5.7-6.4% 0.95 (0.88 to 1.03) 0.19 1.02 (0.99 to 1.06) 0.22
 6.5-6.9% 1.29 (1.18 to 1.41) <0.001 1.31 (1.26 to 1.37) <0.001
Charlson comorbidity index
 0-1 Ref Ref Ref Ref
 2 0.97 (0.87 to 1.09) 0.65 0.98 (0.93 to 1.03) 0.43
 3 0.99 (0.88 to 1.10) 0.82 1.03 (0.98 to 1.09) 0.23
 ≥4 1.44 (1.29 to 1.61) <0.001 1.15 (1.08 to 1.22) <0.001
Laboratory studies obtained on the same day
 HbA1c with or without glucose Ref Ref Ref Ref
 Bundled tests 0.82 (0.77 to 0.88) <0.001 0.93 (0.90 to 0.95) <0.001
Baseline treatment
 Lifestyle Ref Ref Ref Ref
 1 drug 0.95 (0.87 to 1.03) 0.21 0.95 (0.92 to 0.99) 0.02
 2 drugs 1.05 (0.95 to 1.16) 0.38 1.08 (1.03 to 1.14) <0.001
 ≥3 drugs 1.61 (1.41 to 1.85) <0.001 1.39 (1.29 to 1.49) <0.001
Treatment change
 No change Ref Ref Ref Ref
 Deintensification 0.78 (0.65 to 0.93) 0.004 0.80 (0.73 to 0.88) <0.001
 Intensification 1.24 (1.03 to 1.49) 0.02 1.09 (0.98 to 1.20) 0.12
 Drug class change only 1.53 (1.04 to 2.25) 0.03 1.32 (1.05 to 1.67) 0.02
No of healthcare providers per year 1.14 (1.10 to 1.18) <0.001 1.05 (1.04 to 1.07) <0.001
Coordination of care
 Primary care only Ref Ref Ref Ref
 Primary care and specialist care 0.73 (0.60 to 0.87) <0.001 1.02 (0.91 to 1.15) 0.72
 Specialist care only 0.70 (0.55 to 0.90) 0.006 0.77 (0.67 to 0.90) <0.001
 None 3.24 (2.01 to 5.24) <0.001 1.31 (0.94 to 1.81) 0.11
Specialties seen
 Endocrinology 1.87 (1.75 to 2.00) <0.001 1.34 (1.29 to 1.40) <0.001
 Cardiology 1.04 (0.98 to 1.11) 0.19 1.03 (1.00 to 1.06) 0.06
 Ophthalmology 1.06 (0.99 to 1.14) 0.09 1.07 (1.03 to 1.10) <0.001
 Gynecology 1.03 (0.95 to 1.12) 0.41 1.05 (1.02 to 1.09) 0.006
 Nephrology 1.36 (1.23 to 1.52) <0.001 1.09 (1.02 to 1.16) 0.008

Data are odds ratios and 95% confidence intervals (CI) of excessive and frequent testing, versus guideline recommended testing.

Ref=reference group.