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A. Structure of Hrd1. TMD: transmembrane domain. B. A proposed model of Hrd1 in regulation of MHC-II expression. TLR signaling induces Hrd1 gene expression. Hrd1 interacts with and ubiquitinates BLIMP1, a transcription suppresser that inhibits CIITA transcription and consequently to turn on MHC-II expression. MHC-II present foreign antigens to CD4 T cells to initiate the adoptive T cell immune response.
