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. 2015 Aug 27;6(26):21892–21905. doi: 10.18632/oncotarget.5260

Table 1. Key Molecules Up-regulated in hTERT-GFP(+) MCF7 Cells Isolated by FACS: Mitochondria and Glycolysis.

Symbol Description Fold-Upregulation (GPF(+)/GFP(−)) ANOVA
Mitochondrial-Related Proteins (33)
MT-CO2 Cytochrome c oxidase subunit 2, mt-DNA encoded 20.48 7.27E-07
GRPEL1 GrpE protein homolog 1, mitochondrial 11.90 0.006
ECHS1 Enoyl-CoA hydratase, mitochondrial 8.64 9.13E-06
PARK7 Protein DJ-1 8.83 9.61E-07
TOMM7 Mitochondrial import receptor subunit TOM7 8.16 0.025
ATP5B ATP synthase subunit beta, mitochondrial 7.76 1.81E-05
UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 6.75 2.34E-05
FASN Fatty acid synthase 6.60 0.0002
IDH2 Isocitrate dehydrogenase [NADP] 2 5.77 6.95E-06
COX5A Cytochrome c oxidase subunit 5A, mitochondrial 4.99 6.99E-06
ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 4.95 0.0006
MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 4.84 2.55E-05
GATC Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial 4.32 9.33E-06
ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 4.26 7.67E-05
HADH2 HSD17B10/HADH2; 3-hydroxyacyl-CoA dehydrogenase 4.26 0.0002
ACADVL Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial 4.06 0.0001
AK2 Adenylate kinase 2, mitochondrial 4.00 0.0001
IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 3.83 5.05E-05
HADHA Trifunctional enzyme subunit alpha, mitochondrial 3.43 2.89E-05
CS Citrate synthase, mitochondrial 3.40 7.87E-06
HSPD1 60 kDa heat shock protein, mitochondrial 3.30 2.36E-05
DECR1 2,4-dienoyl-CoA reductase, mitochondrial 3.29 0.001
SLC25A10 Mitochondrial dicarboxylate carrier 3.24 0.0001
GSR Glutathione reductase, mitochondrial 3.19 0.01
CYC1 Cytochrome c1, heme protein, mitochondrial 2.91 3.89E-06
NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 2.83 5.39E-05
PRDX5 Peroxiredoxin-5, mitochondrial 2.62 0.0009
PRKDC DNA-dependent protein kinase, catalytic subunit (maintains mt-DNA) 2.25 0.008
UQCR10 Cytochrome b-c1 complex subunit 9 2.22 0.037
SDHA Succinate dehydrogenase complex, subunit A, flavoprotein 2.20 0.001
ABAT 4-aminobutyrate aminotransferase, mitochondrial 2.14 0.003
CYCS Cytochrome c, somatic 2.13 9.35E-05
MRPL15 Mitochondrial ribosomal protein L15 2.11 0.002
Glycolysis and Pentose Phosphate Pathway (PPP) Related Enzymes (17)
GAPDH Glyceraldehyde-3-phosphate dehydrogenase 25.19 1.13E-05
PGAM1 Phosphoglycerate mutase 1 (Brain) 16.82 6.97E-06
G6PD Glucose-6-phosphate 1-dehydrogenase 9.29 1.37E-06
ENO1 Alpha-enolase 9.08 1.08E-05
PKM2 Pyruvate kinase 8.15 0.0016
ALDOA Fructose-bisphosphate aldolase 6.87 3.53E-06
HK2 Hexokinase-2 5.71 2.43E-06
GPI Glucose-6-phosphate isomerase 5.61 4.43E-05
TALDO1 Transaldolase 5.20 0.00095
LDHA L-lactate dehydrogenase A 4.65 2.82E-05
PGD 6-phosphogluconate dehydrogenase, decarboxylating 4.21 3.24E-05
PGK1 Phosphoglycerate kinase 1 3.97 0.01
HK3 Hexokinase-3 3.66 0.0003
PFKP 6-phosphofructokinase type C 3.48 0.0002
PGAM2 Phosphoglycerate mutase 2 3.38 0.006
FBP1 Fructose-1,6-bisphosphatase 1 2.72 0.003
TKT Transketolase 2.15 0.0003