Table 6. hTERT Protein Targets Transcriptionally Up-regulated in Breast Cancer: Focus on Protein Synthesis and Chaperones.
| Symbol | Gene Description | Up-regulation (fold-change) | P-value |
|---|---|---|---|
| Chaperones for Protein Folding (8) | |||
| FKBP4 | Peptidyl-prolyl cis-trans isomerase | 5.02 | 2.95E-06 |
| HSP90AB1 | Heat shock protein HSP 90-beta | 4.93 | 4.03E-06 |
| PPIA | Peptidyl-prolyl cis-trans isomerase A | 4.29 | 3.74E-05 |
| HSPA4 | Heat shock 70kDa protein 4 | 3.75 | 2.18E-04 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | 3.42 | 5.93E-04 |
| HSPA8 | Heat shock cognate 71 kDa protein | 2.54 | 7.06E-03 |
| HSP90B1 | Heat shock protein Grp94 | 2.43 | 9.33E-03 |
| HSPA1B | Heat shock 70kDa protein 1A | 1.56 | 6.29E-02 |
| Ribosomal Proteins (10) | |||
| RPL7 | 60S ribosomal protein L7 | 5.21 | 1.53E-06 |
| RPS2 | 40S ribosomal protein S2 | 4.77 | 7.21E-06 |
| RPL15 | 60S ribosomal protein L15 | 4.60 | 1.28E-05 |
| RPS3A | 40S ribosomal protein S3A | 4.59 | 1.35E-05 |
| RPS5 | 40S ribosomal protein S5 | 4.41 | 2.45E-05 |
| RPL32 | 60S ribosomal protein L32 | 4.03 | 8.74E-05 |
| RPS4X | 40S ribosomal protein S4, X-linked isoform | 3.92 | 1.27E-04 |
| RPS15 | 40S ribosomal protein S15 | 3.72 | 2.41E-04 |
| RPL11 | 60S ribosomal protein L11 | 2.74 | 4.16E-03 |
| Translation initiation factors (2) | |||
| EIF3F | Eukaryotic translation initiation factor 3 subunit F | 5.07 | 2.48E-06 |
| EIF4A2 | Eukaryotic initiation factor 4A-II | 2.68 | 4.83E-03 |
| Elongation factors (4) | |||
| EEF1B2 | Elongation factor 1-beta | 4.08 | 7.56E-05 |
| EEF2 | Elongation factor 2 | 4.01 | 9.29E-05 |
| EEF1G | Elongation factor 1-gamma | 3.71 | 2.44E-04 |
| EEF1A1 | Elongation factor 1 alpha 1 | 3.16 | 1.30E-03 |
| Enzymes for tRNA synthesis (5) | |||
| EPRS | Bifunctional glutamate/proline--tRNA ligase | 4.06 | 8.10E-05 |
| KARS | Lysine--tRNA ligase | 2.81 | 3.49E-03 |
-Transcriptional profiling data derived from the analysis of N=28 breast cancer patients are shown, high-lighting the levels of fold-upregulation observed in the epithelial cancer cell compartment (relative to the tumor stroma), and corresponding p-values derived from the analysis of these clinical samples.