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. 2015 Jun 8;6(26):21918–21933. doi: 10.18632/oncotarget.4204

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Copyright: © 2015 Taverna et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Curcumin caused a decrease of cellular levels of miR-21 and a concomitant increase of its amount in exosomes. Reduced levels of miR-21 in CML cells induce PTEN expression and consequently a decrease of AKT phosphorylation and a down regulation of VEGF expression and release. Curcumin also induced the expression of miR-196b and consequently caused a reduction of Brc-Abl expression.