Table 1. Summary of functional relevance of six mesenchymal genes.
| Transient Silencing in SKOV3 | OC Molecular Subtype p-value^^ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | Entrez Gene Name | Proliferation Ratio^ | Inter-nuclear Distance (∆ Ratio^) | CDH1 QPCR Ratio^ | E-cad Protein Ratio^ | Epi-A vs Rest | Epi-B vs Rest | Mes vs Rest | Stem-A vs Rest | Stem-B vs Rest |
| CD99L2 | CD99 molecule-like 2 | 1.069 | −0.217*** | 1.299 | 1.21 | 3.84e-01 | 1.08e-02 | 2.93e-03 | 3.63e-01 | 2.58e-01 |
| EMP3 | epithelial membrane protein 3 | 1.079 | −0.166*** | 1.114 | 1.39 | 7.07e-10 | 9.85e-01 | 5.20e-56 | 4.48e-24 | 5.41e-04 |
| ITGA5 | integrin, alpha 5 | 1.066 | −0.224*** | 0.956 | 1.43 | 1.25e-08 | 9.70e-15 | 1.27e-77 | 2.11e-21 | 6.11e-02 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 0.943 | −0.118*** | 1.584* | 2.72* | 3.38e-01 | 6.90e-10 | 1.14e-18 | 1.69e-03 | 2.81e-01 |
| VIM | vimentin | 1.058 | −0.007 | 0.803 | 1.42 | 5.72e-02 | 4.72e-35 | 9.35e-18 | 3.79e-01 | 9.41e-06 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 1.003 | −0.100*** | 4.985*** | 23.00*** | 3.32e-05 | 1.20e-29 | 3.05e-56 | 9.95e-10 | 7.12e-07 |
Abbreviations: OC, ovarian cancer; Epi-A, epithelial type A; Epi-B, epithelial type B; Mes, mesenchymal; Stem-A, Stem cell-like A; Stem-B, stem cell-like B.
^
Ratio between siOTP control and si-mesenchymal genes.
^^
p-value by Mann–Whitney Test
*
p < 0.05;
**p < 0.01;
***
p < 0.005 (t-test).