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. 2015 Jun 11;6(26):22152–22166. doi: 10.18632/oncotarget.4158

Figure 4. Perturbation of the mitotic spindle by C5M.

Figure 4

In part A. immunofluorescence of HeLa cells under control conditions (Co) or upon C5M treatment (ON, 100 nM). Tubulin, actin and DNA were simultaneously detected. A Z-slice and a 3D-projection (tubulin and actin) are shown. In part B. a time-lapse experiment was realized under control conditions (Co) or upon C5M treatment (200 nM) with Hek-293 cells expressing GFP-α-tubulin. Elapse times are indicated on each image. A 3D-projection is shown for C5M treated cells to better visualize the spindle orientation that is also illustrated with an arrow.