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. 2015 Jun 10;6(26):22167–22178. doi: 10.18632/oncotarget.4240

Figure 5. The antineoplastic effect of tivantinib is not dependent on c-MET.

Figure 5

A, B, C and D. Effect of c-MET silencing on the expression of c-MET (A) on cell viability (B), apoptosis (C) and cell cycle (D), in Huh7 cells 72 hours after transfection of specific (c-MET-siRNA) or non-coding siRNA (ctrl-siRNA). E, F, G, H and I. Effect of tivantinib on c-MET wild-type DLD1 colorectal cancer cell lines or in c-MET exon 16 knock-out DLD1 (two different clones) as determined by viability assay 6 days after incubation with tivantinib (E), assessment of apoptosis (F) and cell cycle analysis (G) 48 hours after incubation with tivantinib. Western Blot analysis (H) of Mcl-1 and Bcl-xl after 24 hours incubation with tivantinib andtime kinetic of Cyclin B1 activation (I) in these cell lines.