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. 2015 Jun 1;6(26):22179–22190. doi: 10.18632/oncotarget.4246

Figure 5. Integration of exome-seq with RNA-seq and functional implication of selective expression of mutant alleles.

Figure 5

A. Intersection of exome-seq and RNA-seq mutations. B. VAFs of TP53 mutations in the exomes and transcriptomes of PTs and CLMs. C. Correlation between TP53 VAFs and the expression level of p53-target genes (BBC3, BAX, FAS, APAF1, CCNG1, CDKN1A, GADD45A, PTEN, SFN, TSC2, and TP53i3). D. Correlation between APC VAFs and the expression level of WNT-target genes (MYC, CCND1, HNF1A, LEF1, PPARD, JUN, FOSL1, MMP7, AXIN2, NRCAM, TCF4, CLDN1, VEGFA, FGF18, MYCBP, ID2, TERT, LGR5, and FZD7).