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. 2015 Jun 10;6(26):22214–22226. doi: 10.18632/oncotarget.4257

Figure 8. PYK2 links ErbB and IL8 receptors signaling to potentiate cell invasion.

Figure 8

A scheme depicting the positive feedback loop between ErbB receptors, PYK2 and IL8. EGF/HRG binding to ErbB receptors activates PYK2 (pY402), which in turn, enhances STAT3 and ERK1/2 phosphorylation. Phosphorylated STAT3 enhances IL8 transcription and together with phospho-ERK1/2 potentiates MMP9 transcription. Increased levels of MMP9 facilitate cell invasion, and autocrine signaling of IL8 via its CXCR1/2 receptor prolongs ErbB-mediated signaling thereby potentiating the invasive response.